Name two circumstances when a selective serotonin reuptake inhibitor (SSRI) overdose may be potentially dangerous.

  1. massive overdose 
  2. citalopram (Celexa) overdose which can cause QT prolongation and seizures 
Otherwise, SSRI overdoses are generally benign. 


Source

Peer VIII: Physcian's Evaluation and Educational Review in Emergency Medicine, American College of Emergency Physicians
on 12/16/2011 Posted by Dr. Bearemy
Category:

1 comments:

  1. From Poisoning and Drug Overdose (Kent R. Olson et al):
    Toxic dose: unknown, should be >10X the therapeutic dose
    Toxidrome: CNS symptoms, CVS symptoms, Serotonin syndorme

    For elderly patients, the toxic dose level should be lower.

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